Kinetic interaction of nomifensine with a 1, 5-benzodiazepine (clobazam).
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چکیده
منابع مشابه
The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia
Data from genetically modified mice suggest that benzodiazepine (BDZ)-site agonists with improved selectivity for α2-subtype GABAA receptors (α2GABAAR) are potentially useful for the treatment of neuropathic pain. Subtype-selective compounds available for preclinical tests in rodents support this concept but have not been approved for human use, hindering proof-of-concept studies in patients. W...
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Stonier, P.D., A.C. Parrott, and 1. Hindmarch: Clobazam in combination with nomifensine (HOE 8476): effects on mood, sleep, and psychomotor Performance relating to car-driving ability. Drug Dev. Res. S1:047-055, 1982. The effects of three dose regimens of HOE 8476, a combination of nomifensine (25 mg) and clobazam (7.5 mg), placebo, and a combination of amitriptyline (25 mg) and chlordiazepoxid...
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برهمکنش dnaتیموس گاوی طبیعی (ct-dna) با اتیلن دی آمین تترااستات (edta)در بافرtris-hcl با 8/7 ph ( دراین ph،edta به نمک دی سدیم تبدیل می شود) وسسامول در بافر tris-hcl با4/7 ph مورد بررسی قرار گرفته است. edta و سسامول استفاده فراوانی در تکنولوژی غذایی و صنعت شیمیایی دارند. مدل اتصال dna مربوط بهedta بوسیله اسپکتروفتومتری جذب، دورنگ نمایی حلقوی(cd)، ویسکومتری وژل الکتروفورز بررسی شده است. طیفuv ...
15 صفحه اولDeconstructing tolerance with clobazam
OBJECTIVE To evaluate potential development of tolerance to adjunctive clobazam in patients with Lennox-Gastaut syndrome. METHODS Eligible patients enrolled in open-label extension study OV-1004, which continued until clobazam was commercially available in the United States or for a maximum of 2 years outside the United States. Enrolled patients started at 0.5 mg·kg-1·d-1 clobazam, not to exc...
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1 Soules MR, McCarty KS. Leiomyomas: steroid receptor content. Am J Obstet Gynecol 1982;143:6-11. 2 Fraser HM. New prospects for luteinising hormone releasing hormone as a contraceptive and therapeutic agent. Br MedJe 1982;285:990-1. 3 Sutherland IA, White S, Chambers GR, et al. A miniature infuser for the pulsatile administration of LHRH. J Biomed Eng 1984;6:129-33. 4 Chong AP, Baggish MS. Man...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1977
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1977.tb05741.x